Ketamine: a new view on therapeutic opportunities in psychiatric practice

Ketamine: a new view on therapeutic opportunities in psychiatric practice

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This article is a review of evidence-based research in English for the past 15 years turkey airpods thanks to access via a database PubMed and Medline, about the new features out of claimed indications of the well-known short--acting anesthetic, ketamine.Latter being the antagonist of NMDA receptors by activating glutamatergic transmission has antidepressant effects.One intravenous infusion of 0.5 mg/kg of ketamine for 40 minutes can provide fast antidepressant effect, during the bipolar and monopolar resistant depression, especially with high risk of suicide.

Instability of antidepressant effect of ketamine from a few hours to several weeks is roland blues cube amp demonstrated.It is also proved the effectiveness of ketamine in obsessive-compulsive and posttraumatic frustration.Intramuscular, oral and intranasal routes of applications are researched.Ketamin can probably serve as a therapeutic alternative in some patients with pharmacotherapy resistant depression except patients with substance abuse or a history of psychosis.